Category: Blood pressure

Growing old stressfully: chronic stress and prematurely aged cells

Human chromosomes showing telomeres
Human chromosomes (grey) capped by telomeres (white), the structures that prevent damage to DNA with repeated cell divisions. Photograph: public domain

Forty years ago, the Whitehall Study of men working for Britain’s Civil Service famously revealed that those at the bottom of the pecking order were much more likely to die prematurely than those at the top – regardless of other risk factors such as smoking. They had higher mortality rates from all causes, but especially heart disease.

So the lowly paid doorman, whether or not he was a heavy smoker, was more likely to drop dead than the clerk sitting at his desk all day earning more money. As ever, life was deeply unfair. But what was the biological explanation for this health inequality? One theory was that the stress and lack of control over their working lives experienced by men in lowlier jobs were putting their health at risk, though how that worked physiologically was anyone’s guess. (more…)